Equity benchmark Sensex tumbled 379 points on Thursday, tracking losses in index heavyweights HDFC twins, ICICI Bank and Reliance Industries amid a weak trend in global markets. The 30-share BSE index ended 379.14 points or 0.73 per cent lower at 51,324.69. Similarly, the broader NSE Nifty dropped 89.95 points or 0.59 per cent to 15,118.95.