Equity benchmark Sensex tumbled 397 points on Monday, tracking losses in index heavyweights Reliance Industries, HDFC twins and ICICI Bank amid weak macroeconomic cues. After gyrating 1,035.71 points during the day, the 30-share BSE index ended 397 points or 0.78 per cent lower at 50,395.08. The broader NSE Nifty finished 101.45 points or 0.67 per cent down at 14,929.50.