Equity benchmark Sensex tumbled over 300 points in early trade on Thursday, tracking losses in index-heavyweights HDFC twins, ICICI Bank and Reliance Industries amid a largely negative trend in global equities. The 30-share BSE index was trading 302.80 points or 0.58 per cent lower at 52,199.18 in initial deals. Similarly, the broader NSE Nifty declined 93.70 points or 0.59 per cent to 15,673.85.