Equity benchmark Sensex tanked 627 points on Wednesday, dragged by losses in index majors HDFC twins, Reliance Industries and Infosys amid a negative trend in global markets. The 30-share BSE index ended 627.43 points or 1.25 per cent lower at 49,509.15, and the broader NSE Nifty slumped 154.40 points or 1.04 per cent to 14,690.70.